Superantigen recognition by some T cells is strongly influenced by polymorphic residues of
the MHC class II molecule, suggesting that the TCR contacts the class II molecule during …

While recent evidence strongly suggests that the third complementarity determining regions
(CDR3s) of T cell receptors (TCRs) directly contact antigenic peptides bound to major …

The TCR alpha-chain has been implicated in superantigen recognition by some T cells. In
this study, recognition of a retroviral (minor lymphocyte stimulating Ag-1, Mls-1) and a …

The structure of a bacterial superantigen, Staphylococcus aureus enterotoxin B, bound to a
human class II histocompatibility complex molecule (HLA-DR1) has been determined by X …

Superantigens bind to antigen-presenting cells on the outside of the major histocompatibility
complex (MHC) class II molecule and to T cells via the external face of the T cell receptor …

CD4 T cell receptors (TCRs) recognize antigenic peptides presented by self major
histocompatibility complex (MHC) class II molecules as well as non-self MHC class II …

Class II major histocompatibility complex (MHC) molecules present peptides derived from
processed antigen to antigen-specific CD4-positive T cells. In addition, class II molecules …

SUPERANTIGENS are proteins that in association with class II major histocompatibility
complex (MHC)-bearing cells can stimulate vir-tually all T cells that express particular …

Bacterial and retroviral superantigens (SAGs) interact with major histocompatibility complex
(MHC) class II molecules and stimulate T cells upon binding to the V beta portion of the T …

The last few years have seen an enormous jump in our knowledge and understanding of T-
cell activation by superantigens. Clearly, a great number of infectious and parasitic …