Similar to native peptide/MHC ligands, bacterial superantigens have been found to bind with
low affinity to the T cell receptor (TCR). It has been hypothesized that low ligand affinity is …

The T cell receptor (TCR) V beta-determining region of two bacterial superantigens,
staphylococcal enterotoxin A (SEA) and SEE, has been mapped to the COOH-terminal …

Superantigens (SAGs) are a class of disease‐causing and immunostimulatory proteins of
bacterial or viral origin that activate T cells by binding to the Vβ domain of the T‐cell antigen …

Two binding sites for MHC class II have previously been identified on opposite sides of the
superantigen, staphylococcal enterotoxin A (SEA). The sites mediate separate binding …

The previous paper in this series demonstrates that rat T cells developing de novo in the
presence of mouse mammary tumor virus (Mtv) antigens in rat--> severe combined …

T cell epitopes can be defined by the use of synthetic peptides, which when added to APC
efficiently mimic naturally processed Ag. Free peptide is thought to bind to cell-surface MHC …

We have expressed in bacteria a single-chain T cell receptor (scTCR) with specificity for an
HIV gp120-derived peptide bound to the murine MHC-I molecule, H-2Dd. This scTCR …

Publisher Summary Many experiments showed that T cells do not distinguish between
native and denatured antigens, whereas antibody commonly does. T cells and B cells …

C-terminal residues of staphylococcal enterotoxin A (SEA), including H187, D225, and
D227, are involved in moderate affinity binding to MHC class II beta-chain, whereas N …

To investigate the structural and genetic basis of the T cell response to defined
peptide/major histocompatibility (MHC) class II complexes in humans, we established a …