DNA damage in the brain is influenced by endogenous processes and metabolism along
with exogenous exposures. Accumulation of DNA damage in the brain can contribute to …

DNA adducts and strand breaks are induced by various exogenous and endogenous
agents. Accumulation of DNA damage is implicated in many disease processes, including …

Genomic DNA is constantly exposed to various types of exogenous and endogenous
stimulants that induce DNA lesions, including single-strand breaks (SSBs) and double …

Cellular DNA is constantly chemically altered by exogenous and endogenous agents. As all
processes of life depend on the transmission of the genetic information, multiple biological …

Until recently, DNA damage arising from physiological DNA metabolism was considered a
detrimental by-product for cells. However, an increasing amount of evidence has shown that …

In human cells, the integrity of genetic information is constantly challenged by endogenous
and exogenous chemical agents that can induce DNA damage. To counteract the …

Neurons are highly susceptible to DNA damage accumulation due to their large energy
requirements, elevated transcriptional activity, and long lifespan. While newer research has …

DNA damage is a threat to genome integrity and can be a cause of many human diseases,
owing to either changes in the chemical structure of DNA or conversion of the damage into a …

DNA is a remarkable biochemical macromolecule tasked with storing the genetic information
that instructs life on planet Earth. However, its inherent chemical instability within the cellular …

Recent advances in organic chemistry, fluorescent microscopy, and materials science have
created an entirely new range of techniques and probes for imaging DNA damage in …