The stiffness of tumors and their host tissues is much higher than most hydrogels, which are
conventionally used to study in vitro cancer progression. The tumoroid assay is an …

The mechanics of the extracellular matrix (ECM) have long been known to have important
implications for cancer metastasis and cell migration. An atypical increase in tumor ECM …

Recent research has demonstrated that tumor microenvironments play pivotal roles in tumor
development and metastasis through various physical, chemical, and biological factors …

Patient-derived tumor organoids have been established as promising tools for in vitro
modelling of multiple tumors, including cholangiocarcinoma (CCA). However, organoids are …

Clinical evidence supports a role for the extracellular matrix (ECM) in cancer plasticity
across multiple tumor types. The lack of in vitro models that represent the native ECMs is a …

Clinical evidence supports a role for the extracellular matrix (ECM) in cancer risk and
prognosis across multiple tumor types, and numerous studies have demonstrated that …

The extracellular matrix undergoes extensive remodeling during hepatocellular carcinoma
and functions as a critical component of the tumor microenvironment by providing a …

Recent engineering technologies have transformed traditional perspectives of cancer to
include the important role of the extracellular matrix (ECM) in recapitulating the malignant …

The extracellular matrix (ECM) plays an undisputable role in tissue homeostasis and its
deregulation leads to altered mechanical and biochemical cues that impact cancer …

Tumor progression in vitro has traditionally been studied in the context of two-dimensional
(2D) environments. However, it is now well accepted that 2D substrates are unnaturally rigid …