Enzymes are an attractive alternative in the asymmetric syntheses of chiral building blocks.
To meet the requirements of industrial biotechnology and to introduce new functionalities …

This mini review gives an overview over different design approaches and methodologies
applied in rational and semirational enzyme engineering. The underlying principles for …

The discovery of new enzymes, alongside the push to make chemical processes more
sustainable, has resulted in increased industrial interest in the use of biocatalytic processes …

The efficient application of biocatalysts requires the availability of suitable enzymes with
high activity and stability under process conditions, desired substrate selectivity and high …

Abstract Enzymes offering chemo-, regio-, and stereoselectivity enable the asymmetric
synthesis of high-value chiral molecules. Unfortunately, the drawback that naturally …

The strategy of rational design to engineer enzymes is to predict the potential mutants based
on the understanding of the relationships between protein structure and function, and …

Enzymes have been used for a long time as catalysts in the asymmetric synthesis of chiral
intermediates needed in the production of therapeutic drugs. However, this alternative to …

In recent years, several procedures have been reported for the development of biocatalytic
processes. This review focuses on selected examples integrating biocatalysts into a variety …

With the development of enzyme engineering technology, green enzyme catalysis is widely
poised to replace traditional chemical catalysis enabling high enantioselectivity and yielding …

Directed evolution is being used increasingly in industrial and academic laboratories to
modify and improve commercially important enzymes. Laboratory evolution is thought to …