Integrin adhesion receptors connect the extracellular matrix (ECM) to the cytoskeleton and
serve as bidirectional mechanotransducers. During development, angiogenesis, wound …

Cell-generated traction forces induce integrin activation, leading to focal adhesion growth
and cell spreading. It remains unknown, however, whether integrin activation feeds back to …

Cells can detect and react to the biophysical properties of the extracellular environment
through integrin-based adhesion sites and adapt to the extracellular milieu in a process …

Integrin-based adhesion complexes link the cytoskeleton to the extracellular matrix (ECM)
and are central to the construction of multicellular animal tissues. How biological function …

Cells sense and respond to the biochemical and physical properties of the extracellular
matrix (ECM) through adhesive structures that bridge the cell cytoskeleton and the …

Cells govern tissue shape by exerting highly regulated forces at sites of matrix adhesion. As
the major force-bearing adhesion-receptor protein, integrins have a central role in how cells …

Cell-matrix adhesion complexes are multi-protein structures linking the extracellular matrix
(ECM) to the cytoskeleton. They are essential to both cell motility and function by …

Many essential cellular functions in health and disease are closely linked to the ability of
cells to respond to mechanical forces. In the context of cell adhesion to the extracellular …

Mechanical forces are crucial to the regulation of cell and tissue morphology and function. At
the cellular level, forces influence cytoskeletal organization, gene expression, proliferation …

Focal adhesions are clusters of integrin transmembrane receptors that mechanically couple
the extracellular matrix to the actin cytoskeleton during cell migration. Focal adhesions …