Use of GAL4 factor-based yeast assay to quantify the effects of xenobiotics on RXR homodimer and RXR/PPAR heterodimer in scallop Chlamys farreri

Q Wang, J Miao, A Zhao, M Wu, L Pan - Science of The Total Environment, 2022 - Elsevier
Retinoid X receptor (RXR) and peroxisome proliferators-activated receptors (PPAR) have
been shown as important targets of endocrine disrupting effects caused by organotin …

Potencies of organotin compounds in scallop RXRa responsive activity with a GAL4-based reconstituted yeast assay in vitro

A Zhao, J Miao, L Liu, L Pan - Environmental Science and Pollution …, 2022 - Springer
Retinoid X receptor (RXR) has been found to be a major target in various processes of
endocrine disruption from the exposure to organotin compounds (OTCs), including imposex …

[PDF][PDF] Identification and characterization of retinoid X receptors (RXR) in Atlantic cod (Gadus morhua) and their response to organic tin exposure

AV Borge - 2021 - bora.uib.no
As a result of the continuous industrialization and globalization over the last two centuries,
anthropogenic pollutants have been emerging at an alarming rate in areas previously …

Triphenyltin alters lipid homeostasis in females of the ramshorn snail Marisa cornuarietis

A Lyssimachou, JC Navarro, J Bachmann… - Environmental Pollution, 2009 - Elsevier
Molluscs are sensitive species to the toxic effects of organotin compounds, particularly to
masculinisation. Both tributyltin (TBT) and triphenyltin (TPT) have been recently shown to …

Development of a yeast reporter gene assay to detect ligands of freshwater cladoceran Daphnia magna ultraspiracle, a homolog of vertebrate retinoid X receptors

S Ito‐Harashima, Y Tsubouchi… - Journal of Applied …, 2023 - Wiley Online Library
Endocrine‐disrupting chemicals (EDCs) often affect homeostatic regulation in living
organisms by directly acting on nuclear receptors (NRs). Retinoid X receptors (RXRs), the …

Effects of diisodecyl phthalate on PPAR: RXR-dependent gene expression pathways in sea bream hepatocytes

P Cocci, G Mosconi, A Arukwe… - Chemical research in …, 2015 - ACS Publications
Evidence that endocrine-disrupting chemicals (EDCs) may target metabolic disturbances,
beyond interference with the functions of the endocrine systems has recently accumulated …

Functional characterization of retinoid X receptor with an emphasis on the mediation of organotin poisoning in the Pacific oyster (Crassostrea gigas)

W Huang, Q Wu, F Xu, L Li, J Li, H Que, G Zhang - Gene, 2020 - Elsevier
Marine mollusks suffer harmful effects due to environmental organotin compounds such as
tributyltin (TBT) and triphenyltin (TPT). It is known that gastropod imposex caused by …

Occurrence of xenobiotic ligands for retinoid X receptors and thyroid hormone receptors in the aquatic environment of Taiwan

CH Chen, PH Chou, M Kawanishi, T Yagi - Marine pollution bulletin, 2014 - Elsevier
Various synthetic compounds are frequently discharged into the environment via human
activities. Among them, certain contaminants may disrupt normal physiological functions of …

Ecotoxicity of triphenyltin on the marine copepod Tigriopus japonicus at various biological organisations: from molecular to population-level effects

AX Yi, J Han, JS Lee, KMY Leung - Ecotoxicology, 2014 - Springer
Triphenyltin compounds (TPTs), as effective biocides for different industrial and agricultural
purposes, have been detected in coastal marine environments worldwide, in particular in …

Peroxisome proliferator-activated receptor gamma (PPARγ) in brown trout: Interference of estrogenic and androgenic inputs in primary hepatocytes

C Lopes, TV Madureira, N Ferreira, I Pinheiro… - Environmental …, 2016 - Elsevier
Peroxisome proliferator-activated receptor gamma (PPARγ) is a pivotal regulator of lipid and
glucose metabolism in vertebrates. Here, we isolated and characterized for the first time the …