Renal fibrosis is the hallmark of virtually all progressive kidney diseases and strongly
correlates with the deterioration of kidney function. The renin-angiotensin-aldosterone …

The understanding of renal fibrosis in chronic kidney disease (CKD) remains as a challenge.
More than 10% of the population of developed countries suffer from CKD. Proliferation and …

Renal fibrosis is a hallmark of chronic kidney disease. Although considerable achievements
in the pathogenesis of renal fibrosis have been made, the underlying mechanisms of renal …

Fibrosis, a characteristic of all chronic kidney diseases, is now recognized to be an
independent predictor of disease progression. Deposition of pathological matrix in the walls …

Elevated expression of the multifunctional cytokine transforming growth factor β1 (TGF-β1) is
causatively linked to kidney fibrosis progression initiated by diabetic, hypertensive …

Renal fibrosis is a major hallmark of chronic kidney disease, regardless of the initial causes,
and prominent renal fibrosis predicts poor prognosis for renal insufficiency. Transforming …

Renal fibrosis is the inevitable consequence of an excessive accumulation of extracellular
matrix that occurs in virtually every type of chronic kidney disease. The pathogenesis of …

Chronic kidney diseases are emerging as a worldwide public health problem. The
progression of kidney diseases closely correlates with the accumulation of extracellular …

Introduction Diabetic kidney disease (DKD) is the most common cause of end-stage renal
disease (ESRD) worldwide. Currently, there is no effective treatment to completely prevent …

Transforming growth factor-β (TGF-β) is generally considered as a central mediator of fibrotic
diseases. Indeed, much focus has been placed on inhibiting TGF-β and its downstream …