Mitochondrial dysregulation and associated excessive reactive oxygen species (mtROS)
production is a key source of oxidative stress in aging arteries that reduces baseline function …

Key points Reducing excessive oxidative stress, through chronic exercise or antioxidants,
can decrease the negative effects induced by excessive amounts of oxidative stress …

Recognizing the age-related decline in skeletal muscle feed artery (SMFA) vasodilatory
function, this study examined the link between vasodilatory and mitochondrial respiratory …

Objective Enhancing structural and functional integrity of mitochondria is an emerging
therapeutic option against endothelial dysfunction. In this study, we sought to investigate the …

To determine the efficacy of inorganic nitrite supplementation on endothelial function in
humans and mechanisms of action, we performed (1) a randomized, placebo-controlled …

Aims/hypothesis Exercise ameliorates oxidative stress-mediated diabetic vascular
endothelial dysfunction through poorly defined mechanisms. We hypothesised that, in …

This study investigated how different exercise training modalities influence skeletal muscle
mitochondrial dynamics. Healthy [average body mass index (BMI): 25.8 kg/m2], sedentary …

Endurance exercise long has been recognized to not only enhance physical performance
but also bring about beneficial health outcomes. The most studied phenotypic adaptations in …

Mitochondrial dynamics plays an important role in improving cardiovascular homeostasis.
This process refers to the continuous biogenesis, fusion, fission and degradation of …

Key points The results of the present study establish the temporal pattern of age‐related
vascular dysfunction across the adult lifespan in sedentary mice consuming a non‐Western …