We hypothesized that enhanced skeletal muscle mitochondrial function following aerobic
exercise training is related to an increase in mitochondrial transcription factors, DNA …

The concept of enhancing structural integrity of mitochondria has emerged as a novel
therapeutic option for cardiovascular disease. Flow-induced increase in laminar shear stress …

We tested two hypotheses, first that exercise training reverses age-related decrements in
endothelium-dependent dilation in soleus muscle feed arteries and second that this …

Purpose The purpose of the current study was to determine the impact of chronic resistance
training on skeletal muscle mitochondrial respiratory capacity and function. Methods Here …

Aims Physical activity is one of the most potent strategies to prevent endothelial dysfunction.
Recent evidence suggests vaso-protective properties of hydrogen peroxide (H2O2) …

Our translational research group focuses on addressing the problem of exercise defects in
diabetes with basic research efforts in cell and rodent models and clinical research efforts in …

Purpose This study aimed to investigate the effects of single-bout exercise on mitochondrial
function, dynamics (fusion, fission), and mitophagy in cardiac and skeletal muscles. Methods …

Tumor suppressor p53 plays a pivotal role in orchestrating mitochondrial remodeling by
regulating their content, fusion/fission processes, and intracellular signaling molecules that …

Aims Imbalance between pro-and antioxidant species (eg during aging) plays a crucial role
for vascular function and is associated with oxidative gene regulation and modification …

Oxidant stress contributes to the initiation and progression of hypertension (HTN) by
enhancing endothelial dysfunction and/or causing perturbations in nitric oxide homeostasis …