Key points Exercise training effectively improves vascular and skeletal muscle function;
however, these effects of training may be blunted in postmenopausal women as a result of …

Background Endothelial dysfunction associated with hypercholesterolemia is an early event
in atherosclerosis characterized by redox imbalance associated with high superoxide …

Exercise capacity has been related to morbidity and mortality. It consists of an inherited and
an acquired part and is dependent on mitochondrial function. We assessed skeletal muscle …

During exercise, muscle ATP demand increases with intensity, and at the highest power
output, ATP consumption may increase more than 100-fold above the resting level. The rate …

Eccentric exercise (EE) is known to induce damage and dysfunction in skeletal muscle.
However, the possible role of mitochondrial (dys) function, including the vulnerability to …

Routine exercise is widely recognized as cardioprotective. Exercise induces a variety of
effects within the cardiovasculature, including decreased mitochondrial damage and …

Purpose Mitochondria are essential for energy production in the muscle cell and for this they
are dependent upon a sufficient supply of oxygen by the circulation. Exercise training has …

Changes in skeletal muscle respiratory capacity parallel that of aerobic fitness. It is unknown
whether mitochondrial content, alone, can fully account for these differences in skeletal …

Cycles of ischemia-reperfusion (IR) that occur during peripheral arterial disease (PAD) are
associated with significant morbi-mortality, and aging is an irreversible risk factor of PAD …

Endothelial mitochondria play a pivotal role in maintaining endothelial cell (EC)
homeostasis through constantly altering their size, shape, and intracellular localization …