A novel thiosemicarbazone as a promising effective and selective compound for acute leukemia
DM Perondi, AV Jacques, NM Stefanes… - Anti-Cancer …, 2019 - journals.lww.com
Acute leukemias are a heterogeneous group of aggressive malignant neoplasms associated
with severe morbidities due to the nonselectivity of current chemotherapeutic drugs to …
with severe morbidities due to the nonselectivity of current chemotherapeutic drugs to …
[HTML][HTML] Molecular events and cytotoxic effects of a novel thiosemicarbazone derivative in human leukemia and lymphoma cell lines
ÍM Santos-Pirath, LO Walter, MF Maioral… - … /Oncology and Stem Cell …, 2021 - Elsevier
The present study aimed to investigate the cytotoxic effect of 38 new thiosemicarbazone
derivatives on hematological neoplastic cells lines and to select the most effective …
derivatives on hematological neoplastic cells lines and to select the most effective …
Novel thiosemicarbazone derivative 17B interferes with the cell cycle progression and induce apoptosis through modulating downstream signaling pathways
E Bozgeyik, D Tasdemir-Kahraman, K Arman… - Gene Reports, 2020 - Elsevier
Thiosemicarbazones (TSCs) are interesting group of chemical compounds that received
significant levels of attention due their wide range of pharmacological effects including …
significant levels of attention due their wide range of pharmacological effects including …
Discovery of thiosemicarbazone-containing compounds with potent anti-proliferation activity against drug-resistant K562/A02 cells
X Gu, X Li, M Guan, C Jiang, Q Song, N Sun… - Bioorganic & Medicinal …, 2020 - Elsevier
Abstract P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a major obstacle to
successful chemotherapy for leukemia. In this study, a series of thiosemicarbazone …
successful chemotherapy for leukemia. In this study, a series of thiosemicarbazone …
Design, synthesis and in vitro evaluation of new thiosemicarbazone derivatives as potential anticancer agents
Thiosemicarbazones play a pivotal role as potential therapeutic agents for the management
of lung cancer. 4-(4-Cyanophenyl)-1-[(5-arylfuran-2-yl) methylene] thiosemicarbazides (1 …
of lung cancer. 4-(4-Cyanophenyl)-1-[(5-arylfuran-2-yl) methylene] thiosemicarbazides (1 …
G2/M cell cycle arrest and tumor selective apoptosis of acute leukemia cells by a promising benzophenone thiosemicarbazone compound
M Cabrera, N Gomez, F Remes Lenicov, E Echeverría… - PLoS …, 2015 - journals.plos.org
Anti-mitotic therapies have been considered a hallmark in strategies against abnormally
proliferating cells. Focusing on the extensively studied family of thiosemicarbazone (TSC) …
proliferating cells. Focusing on the extensively studied family of thiosemicarbazone (TSC) …
Design, synthesis, cytotoxic screening and molecular docking studies of novel hybrid thiosemicarbazone derivatives as anticancer agents
FZ Mohammed, YW Rizzk, IM El Deen… - Chemistry & …, 2021 - Wiley Online Library
Thiosemicarbazones have been the focus of scientists owing to their broad clinical
anticancer range. Herein, A Series of new thiosemicarbazone derivatives 5–9 were …
anticancer range. Herein, A Series of new thiosemicarbazone derivatives 5–9 were …
The effect of novel synthetic semicarbazone-and thiosemicarbazone-linked 1, 2, 3-triazoles on the apoptotic markers, VEGFR-2, and cell cycle of myeloid leukemia
Abstract Vascular Endothelial Growth Factor II (VEGFR-2) has been proved as a rational
target in cancer therapy. Although currently prescribed VEGFR-2 inhibitors are showing …
target in cancer therapy. Although currently prescribed VEGFR-2 inhibitors are showing …
[HTML][HTML] Determination of anticancer potential of a novel pharmacologically active thiosemicarbazone derivative against colorectal cancer cell lines
Thiosemicarbazones have received noteworthy attention due to their numerous
pharmacological activities. Various thiosemicarbazone derivatives have been reported to …
pharmacological activities. Various thiosemicarbazone derivatives have been reported to …
Characterization of the anticancer effects of S115, a novel heteroaromatic thiosemicarbazone compound, in vitro and in vivo
M Liu, L Xiao, Y Dong, Y Liu, L Cai, W Xiong… - Acta pharmacologica …, 2014 - nature.com
Aim: To investigate the anticancer effects of S115, a novel heteroaromatic
thiosemicarbazone compound in vitro and in vivo. Methods: The anti-proliferative action of …
thiosemicarbazone compound in vitro and in vivo. Methods: The anti-proliferative action of …