Inflammatory‐activated glia are seen in numerous central nervous system (CNS)
pathologies and can kill nearby neurons through the release of cytotoxic mediators. Glia …

Glia undergo inflammatory activation in most CNS pathologies and are capable of killing
cocultured neurons. We investigated the mechanisms of this inflammatory …

In inflammatory, infectious, ischemic, and neurodegenerative pathologies of th central
nervous system (CNS) glia become “activated” by inflammatory mediators, and express new …

Hypoxia/ischaemia is known to trigger neuronal death, but the role of neuronal nitric oxide
synthase (nNOS) in this process is controversial. Nitric oxide (NO) inhibits cytochrome …

The role of inflammatory cytokines in the pathogenesis of neurological diseases is not well
understood. The neurotoxic effects of cytokines could be mediated by immunostimulation of …

In vitro exposure of microglial cells to hypoxia induces cellular activation. Also, in vivo
studies of glial activation following ischemic hypoxia have shown that neuronal cell death is …

Inflammatory neurodegeneration contributes to a wide variety of brain pathologies. A
number of mechanisms by which inflammatory-activated microglia and astrocytes kill …

Inflammation contributes to a wide variety of brain pathologies, apparently via glia killing
neurons. A number of mechanisms by which inflammatory-activated microglia and …

Nitric oxide (NO) contributes to neuronal death in cerebral ischemia and other conditions.
Astrocytes are anatomically well positioned to shield neurons from NO because astrocyte …

The role of inflammatory cytokines in the pathogenesis of neurological disorders is not
entirely clear. The neurotoxic effects of cytokines, and perhaps indirectly bacterial …