Here we identify a component of the nuclear RNA cap-binding complex (CBC), Ars2, that is
important for miRNA biogenesis and critical for cell proliferation. Unlike other components of …

Cancer is viewed as a genetic disease. According to the currently accepted model of
carcinogenesis, several consequential mutations in oncogenes or tumor suppressor genes …

The outcome of an inflammatory response depends upon the coordinated regulation of a
variety of both pro‐inflammatory and anti‐inflammatory cytokines and other proteins …

The chromatin remodeling complex SWI/SNF is an important epigenetic regulator that
includes one Brm or BRG1 molecule as catalytic subunit. Brm and BRG1 do not function …

During their quest for growth, adaptation, and survival, cancer cells create a favorable
environment through the manipulation of normal cellular mechanisms. They increase …

Cancers have distinct miRNA expression profiles that contribute to the pathobiology of the
disease. In hormone-responsive cancers, the regulatory interactions between the SHR and …

Gene expression is mostly controlled at the level of the transcription initiation. The
transcription control regions of protein-encoding genes include: the core promoter, where …

RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and
important biological functions. They are critical to maintain the transcriptome through post …

Alterations and personal variations of RNA interactions have been mechanistically coupled
with disease etiology and phenotypical variations. RNA biomarkers, RNA mimics, and RNA …

Background Colorectal cancer (CRC) is a frequently occurring tumor. Although a number of
long noncoding RNAs have been researched in CRC, the expression, function and …