Aim: Although aberrant DNA methylation has been described in rheumatoid arthritis (RA), no
studies have interrogated this epigenetic modification in early disease. Following recent …

Changes to the DNA methylome have been described in patients with rheumatoid arthritis
(RA). In previous work, we reported genome-wide methylation differences in T-lymphocyte …

Multiple reports now describe changes to the DNA methylome in rheumatoid arthritis and in
many cases have analyzed methylation in mixed cell populations from whole blood …

Objective Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly
targets joints. Monocytes and macrophages are critical in RA pathogenesis and contribute to …

Objectives Epigenetics can influence disease susceptibility and severity. While DNA
methylation of individual genes has been explored in autoimmunity, no unbiased systematic …

Epigenetic regulation of immune cell types could be critical for the development and
maintenance of autoimmune diseases like rheumatoid arthritis (RA). B cells are highly …

Stratifying patients on the basis of molecular signatures could facilitate development of
therapeutics that target pathways specific to a particular disease or tissue location. Previous …

Background The genetic risk associated with rheumatoid arthritis (RA) includes genes
regulating DNA methylation, one of the hallmarks of epigenetic re-programing, as well as …

Background Rheumatoid arthritis (RA) is a chronic, immune-mediated inflammatory disease
of the joints that has been associated with variation in the peripheral blood methylome. In …

Objective To compare DNA methylation in subjects positive vs negative for anti-citrullinated
protein antibodies (ACPA), a key serological marker of rheumatoid arthritis (RA) risk …