Standard chemotherapy administered systemically has a limited efficacy in the treatment of
brain tumors. One of the major obstacles in the treatment of brain neoplasias is the …

The blood–brain barrier (BBB) is a complex functional barrier composed of endothelial cells,
pericytes, astrocytic endfeets and neuronal cells. This highly organized complex express a …

A prerequisite for the efficacy of any cancer drug is that it reaches the tumor in therapeutic
concentrations. This is difficult to accomplish in most systemic solid tumors because of …

The blood–brain barrier (BBB) is of pivotal importance to maintain homeostasis of the CNS,
as it closely regulates the composition of the interstitial fluid in the brain. Unfortunately …

Systemically administered chemotherapy is not very effective in the treatment of primary or
metastatic brain tumours. An important reason for this low efficacy is insufficient drug …

Drug delivery to the brain is influenced by the blood–brain barrier (BBB) and blood–tumor
barrier (BTB) to an extent that is still debated in neuro-oncology. In this paper, we studied the …

OBJECTIVE: This article reviews historical aspects of the blood-brain barrier (BBB) and
recent advances in mechanisms to deliver therapeutic agents across the BBB for the …

Resection of brain tumors is followed by chemotherapy and radiation to ablate remaining
malignant cell populations. Targeting these populations stands to reduce tumor recurrence …

The presence of barriers, such as the blood–brain barrier (BBB) and brain–tumor barrier
(BTB), limits the penetration of antineoplastic drugs into the brain, resulting in poor response …

The blood-brain barrier (BBB) is a gate that controls the influx and efflux of a wide variety of
substances and consequently restricts the delivery of drugs into the central nervous system …