Engram size varies with learning and reflects memory content and precision

J Leake, R Zinn, LH Corbit, MS Fanselow… - Journal of …, 2021 - Soc Neuroscience
Memories are rarely acquired under ideal conditions, rendering them vulnerable to profound
omissions, errors, and ambiguities. Consistent with this, recent work using context fear …

Hippocampus and amygdala fear memory engrams re-emerge after contextual fear relapse

Y Zaki, W Mau, C Cincotta, A Monasterio… - …, 2022 - nature.com
The formation and extinction of fear memories represent two forms of learning that each
engage the hippocampus and amygdala. How cell populations in these areas contribute to …

Oscillatory and non‐oscillatory brain activity reflects fear expression in an immediate and delayed fear extinction task

P Bierwirth, MI Antov, U Stockhorst - Psychophysiology, 2023 - Wiley Online Library
Fear extinction is pivotal for inhibiting fear responding to former threat‐predictive stimuli. In
rodents, short intervals between fear acquisition and extinction impair extinction recall …

Adrenergic transmission facilitates extinction of conditional fear in mice

CK Cain, AM Blouin, M Barad - Learning & memory, 2004 - learnmem.cshlp.org
Extinction of classically conditioned fear, like its acquisition, is active learning, but little is
known about its molecular mechanisms. We recently reported that temporal massing of …

Fear reduction without fear through reinforcement of neural activity that bypasses conscious exposure

A Koizumi, K Amano, A Cortese, K Shibata… - Nature human …, 2016 - nature.com
Fear conditioning is a fundamentally important and preserved process across species,. In
humans it is linked to fear-related disorders such as phobias and post-traumatic stress …

[HTML][HTML] From extinction learning to anxiety treatment: Mind the gap

JK Carpenter, M Pinaire, SG Hofmann - Brain sciences, 2019 - mdpi.com
Laboratory models of extinction learning in animals and humans have the potential to
illuminate methods for improving clinical treatment of fear-based clinical disorders. However …

Analysis of coherent activity between retrosplenial cortex, hippocampus, thalamus, and anterior cingulate cortex during retrieval of recent and remote context fear …

KA Corcoran, BJ Frick, J Radulovic, LM Kay - Neurobiology of Learning and …, 2016 - Elsevier
Memory for contextual fear conditioning relies upon the retrosplenial cortex (RSC)
regardless of how long ago conditioning occurred, whereas areas connected to the RSC …

[HTML][HTML] Enhanced synchronization between prelimbic and infralimbic cortices during fear extinction learning

M Watanabe, A Uematsu, JP Johansen - Molecular Brain, 2021 - Springer
The ability to extinguish aversive memories when they are no longer associated with danger
is critical for balancing survival with competing adaptive demands. Previous studies …

Reappraisal is less effective than distraction in downregulation of neural responses to physical threats—An event‐related potential investigation

AK Adamczyk, M Wyczesany, K Roelofs… - …, 2023 - Wiley Online Library
Evolutionary threats (ETs), such as predatory animals and heights, elicit stronger fear
responses and are more often the subject of specific phobias, as compared to modern …

Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala

R Nguyen, K Koukoutselos, T Forro, S Ciocchi - Science Advances, 2023 - science.org
Extinction memory retrieval is influenced by spatial contextual information that determines
responding to conditioned stimuli (CS). However, it is poorly understood whether contextual …