The aetiology of sarcoidosis is unclear. Single nucleotide polymorphisms (SNPs) in
transforming growth factor (TGF)-β2 and-β3 have been reported to be associated with the …

Study objectives Pulmonary fibrosis develops in approximately 25% of patients with chronic
sarcoidosis. Transforming growth factor (TGF)-β1 plays a central role in fibrosis, and …

SETTING: Transforming growth factor-beta (TGF-β) plays an important role in many
diseases, influencing as it does such processes as immune responses, fibrosing processes …

Background In sarcoidosis, the direction and intensity of immunological reactions involved in
disease pathophysiology is affected by variation in the genes coding for effector and …

Background Sarcoidosis is a systemic granulomatous disease of unknown aetiology, in
which genetic factors, especially the genes of the highly polymorphic MHC region, seem to …

Methods In 51 sarcoidosis patients and 72 healthy blood donors, genotyping for the named
PMs was performed by PCR methodology and restriction enzyme digestion. Patients were …

Transforming growth factor-beta (TGF-beta) is a cytokine that promotes extracellular matrix
accumulation and inhibits matrix degradation. Although the natural course of sarcoidosis is …

We have analyzed the HLA-DRB1 alleles and-308 TNF-a gene polymorphism in 78
sarcoidosis patients and 50 controls. The sarcoidosis group as a whole did not show any …

This study was designed to evaluate the relationship between the presence of tumor
necrosis factor (TNF) polymorphisms, human leukocyte antigen (HLA)‐DRB1* 03 linkage …

Sarcoidosis is a multisystem, granulomatous disease that most often affects the lungs. The
clinical course is highly variable; many patients undergo spontaneous remission, but up to a …