In this study, we investigated whether B cells play a role in the induction and maintenance of
CD8 T cell memory after immunization with an intracellular bacterium, Listeria …

Infection with Listeria monocytogenes elicits expansion in numbers of Ag-specific CD8+ T
cells, which then undergo programmed contraction. The remaining cells undergo further …

CD4+ T cell help is important for the generation of CD8+ T cell responses. We used
depleting anti-CD4 mAb to analyze the role of CD4+ T cells for memory CD8+ T cell …

CD4 T cells are known to assist the CD8 T cell response by activating APC via CD40-CD40
ligand (L) interactions. However, recent data have shown that bacterial products can directly …

Interferon (IFN)-γ plays an important role in the innate immune response against intracellular
bacterial pathogens. It is commonly thought that natural killer cells are the primary source of …

The T cell response to infection consists of clonal expansion of effector cells, followed by
contraction to memory levels. It was previously thought that the duration of infection …

Following a primary immune response, a portion of effector T cells gives rise to long-lived
memory cells. Although primary expansion and differentiation of effector CD8 T cells is …

The intestinal mucosal CD8 T cell response to infection with Listeria monocytogenes was
measured using MHC class I tetramers and was compared with the response in peripheral …

Abstract Ag-specific Th1 and Th2 cytokine-producing CD4 T cells were quantitated in
secondary lymphoid and tertiary tissues following oral Listeria monocytogenes infection …

CD8 T cells play a critical role in the control and eradication of intracellular pathogens.
Increased understanding of CD8 T cell biology provides insight that can be translated into …