Both CD4+ T cell help and IL-2 have been postulated to “program” activated CD8+ T cells for
memory cell development. However, the linkage between these two signals has not been …

Previous studies revealed the existence of foreign antigen-specific memory phenotype CD8
T cells in unimmunized mice. Considerable evidence suggests this population, termed …

The mechanisms underlying the genesis and maintenance of T cell memory remain unclear.
In this study, we examined the evolution of a complex, antigen-specific T cell population …

ABSTRACT β2 (CD18) integrins with α-chains CD11a,-b,-c, and-d are important adhesion
molecules necessary for leukocyte migration and cellular interactions. CD18 deficiency …

Dynamic interactions between CD4+ T cells and B cells are needed for humoral immunity
and CD4+ T cell memory. It is not known whether B cells are needed early on to induce the …

ABSTRACT CD4 T-cell help is required for optimal memory CD8 T-cell responses. We have
found that engaging preexisiting CD4 Th1, but not Th2, memory cells at the time of CD8 T …

Chronic infection results in continuous formation and exhaustion of effector CD8 T cells and
in failure of memory CD8 T cell development. Expression of CD70 and other molecules that …

A critical aim of vaccine‐related research is to identify the mechanisms by which memory T
cells are formed and maintained over long periods of time. In recent years, we have …

Expression of IL-7Rα (CD127) has been suggested as a major determinant in the survival of
memory T cell precursors. We investigated whether constitutive expression of IL-7Rα on T …

Although the role of CD28-B7 interaction in the activation of naive T cells is well established,
its importance in the generation and maintenance of T cell memory is not well understood. In …