Expression of IL-7Rα (CD127) has been suggested as a major determinant in the survival of
memory T cell precursors. We investigated whether constitutive expression of IL-7Rα on T …

Mice that survived an immunizing infection with Listeria monocytogenes remained
specifically resistant to lethal secondary infection for several months. This acquired, long …

The characteristics of CD8+ T cells responsible for memory responses are still largely
unknown. Particularly, it has not been determined whether different activation thresholds …

The immune response against the intracellular bacterium Listeria monocytogenes involves
both CD4+ and CD8+ T cells. We used the MHC class II-presented peptide listeriolysin 189 …

Memory T cells can persist for extended periods in the absence of antigen, and long-term T
cell immunity is often seen after acute infections. Paradoxically, there have been …

Apoptosis is a critical regulator of homeostasis in the immune system. In this study we
demonstrate that memory CD8+ T cells are more resistant to apoptosis than naive cells. After …

Immunization in the absence of CD4+ T cell help results in defective CD8+ T cell memory,
deficient recall responses and diminished protective immunity. Here we investigated at what …

Memory CD8 T cells acquire effector memory cell properties after reinfection and may reach
terminally differentiated, senescent states (“Hayflick limit”) after multiple infections. The …

Limited studies have addressed the ability of γδ T cells to become memory populations. We
previously demonstrated that WC1. 1+ γδ T cells from ruminants vaccinated with killed …

During infection with lymphocytic choriomeningitis virus, CD8+ T cells differentiate rapidly
into effectors (CD62L low CD44 high) that differentiate further into the central memory …