Sepsis remains the leading cause of mortality in intensive care units and an intractable
condition due to uncontrolled inflammation together with immune suppression. Dysfunction …

Sepsis-induced lymphocyte and dendritic cell apoptosis contributes to immunosuppression,
resulting in an inability to eradicate the primary infection and a propensity to acquire …

Sepsis is characterized by life-threatening organ dysfunction caused by a deregulated host
response to infection. Autophagy is one of the innate immune defense mechanisms against …

Autophagy is one of the innate immune defense mechanisms against microbial challenges.
Previous in vitro and in vivo models of sepsis demonstrated that autophagy was activated …

Sepsis is a systemic inflammatory disease with infection, and autophagy has been shown to
play an important role in sepsis. This review summarizes the main regulatory mechanisms of …

Sepsis is a systemic inflammatory response syndrome caused by infection. The core
mechanism underlying sepsis is immune dysfunction, with macrophages, as important cells …

Autophagy is recognized as a lysosomal degradation pathway important for cellular and
organismal homeostasis. Accumulating evidence has demonstrated that autophagy is a …

Sepsis-induced acute lung injury (ALI) is a life-threatening syndrome with high mortality and
morbidity, resulting in a heavy burden on family and society. As a key factor that maintains …

Background Although the role of autophagy in sepsis has been characterized in several
organs, its role in the adaptive immune system remains to be ascertained. This study aimed …

The inflammatory response is an energy-intensive process. Consequently, metabolism is
closely associated with immune function. The autophagy machinery plays a role in …