Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation

E Martínez-Martínez, V Cachofeiro, E Rousseau… - Molecular and cellular …, 2015 - Elsevier
Abstract Interleukin-33 (IL-33) but not soluble ST2 (sST2) exerts anti-inflammatory and
protective effects in several tissues. Aldosterone, a proinflammatory mediator which …

Effects of obesity on IL-33/ST2 system in heart, adipose tissue and liver: study in the experimental model of Zucker rats

R Ragusa, M Cabiati, MA Guzzardi, A D'Amico… - … and molecular pathology, 2017 - Elsevier
Abstract Suppression of tumorigenicity 2 (ST2) mediates the effect of Interleukin-33 (IL-33).
Few data are reported on the relationship between IL-33/ST2 and obesity. We aimed to …

Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice

AM Miller, DL Asquith, AJ Hueber… - Circulation …, 2010 - Am Heart Assoc
Rationale: Chronic low-grade inflammation involving adipose tissue likely contributes to the
metabolic consequences of obesity. The cytokine interleukin (IL)-33 and its receptor ST2 are …

Severe obesity increases adipose tissue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endothelial cells of human adipose tissue

M Zeyda, B Wernly, S Demyanets, C Kaun… - International journal of …, 2013 - nature.com
Objective: Obesity is associated with chronic inflammation of the adipose tissue, which
contributes to obesity-associated complications such as insulin resistance and type 2 …

A role for soluble ST2 in vascular remodeling associated with obesity in rats

E Martinez-Martinez, M Miana, R Jurado-Lopez… - PLoS …, 2013 - journals.plos.org
Background The function of the Interleukin-33 (IL-33)/ST2 system has been mainly
investigated on immunological aspects, but recent data suggest that this pathway plays also …

IL-33 reverses an obesity-induced deficit in visceral adipose tissue ST2+ T regulatory cells and ameliorates adipose tissue inflammation and insulin resistance

JM Han, D Wu, HC Denroche, Y Yao… - The Journal of …, 2015 - journals.aai.org
Obesity is associated with insulin resistance and inflammation thought to be caused by a
visceral adipose tissue (VAT)–localized reduction in immunoregulatory cells and increase in …

IL-33 at the Crossroads of Metabolic Disorders and Immunity

L Tu, L Yang - Frontiers in Endocrinology, 2019 - frontiersin.org
As a cytokine in interleukin-1 (IL-1) family, interleukin-33 (IL-33) usually exists in the
cytoplasm and cell nucleus. When the cells are activated or damaged, IL-33 can be secreted …

IL-33 in obesity: where do we go from here?

MFA de Oliveira, A Talvani, E Rocha-Vieira - Inflammation Research, 2019 - Springer
IL-33 is a cytokine that belongs to the IL-1 family and is classically associated with type 2-
like immune responses. In the adipose tissue, IL-33 is related to the beiging of adipocytes …

[HTML][HTML] IL-33-driven ILC2/eosinophil axis in fat is induced by sympathetic tone and suppressed by obesity

X Ding, Y Luo, X Zhang, H Zheng, X Yang… - The Journal of …, 2016 - ncbi.nlm.nih.gov
Group 2 innate lymphoid cells (ILC2s) in white adipose tissue (WAT) promotes WAT
browning and assists in preventing the development of obesity. However, how ILC2 in …

Effects of IL-33 on 3T3-L1 cells and obese mice models induced by a high-fat diet

Y Kai, J Gao, H Liu, Y Wang, C Tian, S Guo… - International …, 2021 - Elsevier
Obesity is a syndrome that attributes to many factors such as genetics, diet, lifestyle and
environment, which includes an imbalance of immune regulation. IL-33, as a new member of …