[HTML][HTML] Adenosine A2A receptor mRNA expression in Parkinson's disease

MJ Hurley, DC Mash, P Jenner - Neuroscience letters, 2000 - Elsevier
The expression of the human adenosine A2A receptor was examined by reverse
transcription polymerase chain reaction in post-mortem human brain tissue that was …

Adenosine A2a receptor expression in striatal neurons: Implications for basal ganglia pathophysiology

SN Schiffmann, P Halleux, R Menu… - Drug development …, 1993 - Wiley Online Library
Two dog adenosine receptors have been recently cloned. They were pharmacologically
characterized as an A1 and the A2a receptor, respectively. The adenosine A2a receptor is …

Adenosine A2 receptors: selective localization in the human basal ganglia and alterations with disease

MI Martinez-Mir, A Probst, JM Palacios - Neuroscience, 1991 - Elsevier
Adenosine A2 receptors were labeled and visualized by autoradiography in tissue sections
of the human brain using the A2-selective agonist ligand [3 H](2-p-(2-car☐ yethyl) …

Adenosine A2A receptor gene expression in the normal striatum and after 6-OH-dopamine lesion

A Kaelin-Lang, P Liniger, A Probst, T Lauterburg… - Journal of neural …, 2000 - Springer
Adenosine A 2A receptors are present on enkephalinergic medium sized striatal neurons in
the rat and have an important function in the modulation of striatal output. In order to …

A2 adenosine receptors: their presence and neuromodulatory role in the central nervous system

S Latini, M Pazzagli, G Pepeu, F Pedata - General Pharmacology: The …, 1996 - Elsevier
1. Adenosine is an endogenous neuromodulator that exerts its depressant effect on neurons
by acting on the A 1 adenosine receptor subtype. Excitatory actions of adenosine, mediated …

Aspects of the general biology of adenosine A2A signaling

BB Fredholm, Y Chern, R Franco, M Sitkovsky - Progress in neurobiology, 2007 - Elsevier
Many of our current hopes of finding better ways to treat Parkinson's disease or to stop its
progression rely on studies of adenosine A2A receptors in the brain. Yet any drug targeting …

Distribution of adenosine A2 receptor mRNA in the human brain

SN Schiffmann, F Libert, G Vassart… - Neuroscience …, 1991 - Elsevier
The distribution of the messenger RNA coding for the recently cloned adenosine A 2
receptor was studied in the human brain using in situ hybridization histochemistry. A 2 …

Neuroprotection by adenosine A2A receptor blockade in experimental models of Parkinson's disease

K Ikeda, M Kurokawa, S Aoyama… - Journal of …, 2002 - Wiley Online Library
Adenosine A2A receptors are abundant in the caudate‐putamen and involved in the motor
control in several species. In MPTP‐treated monkeys, A2A receptor‐blockade with an …

Cellular distribution of adenosine A2A receptor mrna in the primate striatum

P Svenningsson, C Le Moine, I Aubert… - Journal of …, 1998 - Wiley Online Library
The cellular expression of adenosine A2A receptor mRNA in the adult monkey and human
striatum was examined by using single and double in situ hybridization with ribonucleotide …

Adenosine A2 receptors regulate the gene expression of striatopallidal and striatonigral neurons

SN Schiffmann, JJ Vanderhaeghen - Journal of Neuroscience, 1993 - Soc Neuroscience
Adenosine acts as a neuromodulator through A1 and A2 receptors. The adenosine analogs
have been recognized, among other effects, as strong depressors of the locomotor activity …