As the incidence of Gram-negative bacterial infections for which few effective treatments
remain increases, so does the contribution of drug-hydrolyzing β-lactamase enzymes to this …

Importance of the field: β-Lactam antibiotics are among the most frequently prescribed
antibiotics used to treat bacterial infections. However, their utility is being threatened by the …

β-Lactams are the most widely used class of antibiotics. Since the discovery of
benzylpenicillin in the 1920s, thousands of new penicillin derivatives and related β-lactam …

The increasing incidence and prevalence of multi-drug resistance (MDR) among
contemporary Gram-negative bacteria represents a significant threat to human health. Since …

Combinations of β-lactams and β-lactamase inhibitors have become one of the most
successful antibacterial strategies in our global battle against bacterial infections. The …

Penicillin, the first of the β-lactam antibiotics, was introduced into medical practice in the
1940s. Since then, a large number of different β-lactams, including penicillins …

Since the introduction of penicillin, β-lactam antibiotics have been the antimicrobial agents
of choice. Unfortunately, the efficacy of these life-saving antibiotics is significantly threatened …

Resistance to β-lactam antibiotics in Gram-negative bacteria is commonly associated with
production of β-lactamases, including extended-spectrum β-lactamases (ESBLs) and …

β-lactam antibiotics (BLAs) are crucial molecules among antibacterial drugs, but the
increasing emergence of resistance to them, developed by bacteria producing β-lactamase …

Introduction: The burden of antimicrobial resistance among Gram-negative bacteria is
increasing and growing into a major threat of public health. Treatment options for …