Hypertension produces myocyte hypertrophy and increases the extracellular matrix. In order
to determine the composition of the extracellular matrix we studied the hearts from 14 …

Objective To investigate pathologic fibrosis and connective tissue matrix in left ventricular
hypertrophy due to chronic arterial hypertension in humans. Design and methods …

The heart in pressure overload is threatened by the development of diastolic and systolic
dysfunction even in the absence of coronary artery disease. In pressure overload, systolic …

The extracellular structural protein, collagen, is responsible for the functional integrity of the
myocardium permitting reversible interdigitation and transmission of force between …

The interstitial space of the myocardium is composed of nonmyocyte cells and a highly
organized collagen network which serves to maintain the architecture and mechanical …

Hypertension induced in rats by suprarenal banding has a blood pressure elevating effect
that is accompanied by the occurrence of cardiac hypertrophy and fibrosis. This …

An exaggerated interstitial and perivascular deposition of fibrillar collagen has been
demonstrated in myocardial hypertrophy due to hypertension. 3 Mechanical stress forces …

Cardiac hypertrophy secondary to a sudden aortic pressure overload results in the
remodeling of myocytes and extracellular matrix components. Hydroxyproline quantitation to …

Pictures certainly are worth a thousand words in the case of the structureof the connective
tissue skeleton of normal and diseased myocardium. This report reviews the …

Pathological left ventricular hypertrophy in renovascular hypertension is associated with the
accumulation of fibrillar collagen within the extracellular space and around intramyocardial …