Role of nitric oxide in gastrointestinal inflammatory and ulcerative diseases: perspective for drugs development

MD Barrachina, J Panes… - Current pharmaceutical …, 2001 - ingentaconnect.com
Nitric oxide is a ubiquitous molecule involved in a variety of biological processes. The
specific action of NO depends on its enzymatic sources namely neuronal nitric oxide …

Nitric oxide and intestinal inflammation

P Kubes, DM McCafferty - The American journal of medicine, 2000 - Elsevier
Inflammation of the intestinal tract remains a very serious concern in the clinical setting.
Unfortunately, to date, the mechanisms underlying many inflammatory conditions such as …

Nitric oxide: a regulator of mucosal defense and injury

SN Elliott, JL Wallace - Journal of gastroenterology, 1998 - Springer
There is an abundance of evidence that nitric oxide plays a critical role in regulating several
components of gastrointestinal mucosal defense. Suppression of nitric oxide synthesis …

Nitric oxide-a mediator of inflammation or mucosal defence

BJR Whittle - European journal of gastroenterology & hepatology, 1997 - journals.lww.com
Nitric oxide (NO) can exert both protective and proinflammatory actions in the
gastrointestinal tract. NO, formed physiologically by constitutive NO synthases, regulates …

New issues about nitric oxide and its effects on the gastrointestinal tract

MJ Martin, MD Jimenez, V Motilva - Current pharmaceutical …, 2001 - benthamdirect.com
Over the last years the important role of nitric oxide (NO) as endogenous modulator of
numerous physiological functions has been shown. NO is involved in the regulation of blood …

III. A molecular prelude to intestinal inflammation

MJS Miller, M Sandoval - American Journal of Physiology …, 1999 - journals.physiology.org
Nitric oxide (NO) synthesis is markedly augmented in states of inflammation, largely due to
the expression of inducible nitric oxide synthase (iNOS). Although NO has anti-inflammatory …

Current roles of nitric oxide in gastrointestinal disorders

CH Cho - Journal of Physiology-Paris, 2001 - Elsevier
It has been confusing as to what roles nitric oxide (NO) has in different physiological and
pathological mechanisms in various diseases. In the gastrointestinal tract, NO can be either …

Nitric oxide-modulating agents for gastrointestinal disorders

BJR Whittle - Expert opinion on investigational drugs, 2005 - Taylor & Francis
Almost 20 years after the identification of the biological role of nitric oxide (NO), the full
therapeutic potential of novel agents that mimic the activity of NO or interfere with its …

Paradoxical roles of different nitric oxide synthase isoforms in colonic injury

PL Beck, R Xavier, J Wong, I Ezedi… - American Journal …, 2004 - journals.physiology.org
Nitric oxide (NO) is a free radical that is largely produced by three isoforms of NO synthase
(NOS): neuronal (nNOS), endothelial (eNOS), and inducible (iNOS). NO regulates numerous …

Nitric oxide in gastrointestinal health and disease

V Shah, G Lyford, G Gores, G Farrugia - Gastroenterology, 2004 - Elsevier
Nitric oxide is an intracellular and intercellular messenger with important functions in a
number of physiologic and pathobiologic processes within gastroenterology and …