The physiological mechanisms that regulate reactive hyperemia are not fully understood.
We postulated that the endothelial P2Y 1 receptor that release vasodilatory factors in …

Background The endothelial ADP receptor P2Y 1 is responsible for a large part of the
reactive hyperemia following cardiac ischemia. Tissue plasminogen activator (t-PA) …

Activation of ADP-sensitive P2Y1 receptors has been proposed as an integral step in the
putative “nucleotide axis” regulating coronary blood flow. However, the specific mechanism …

Objective—Reperfusion therapy for myocardial infarction is limited by a significant
reocclusion rate and less optimal myocardial tissue perfusion due to excessive platelet …

Adenosine‐5′‐triphosphate (ATP) is a potent coronary vasodilator. Because of the efficient
hydrolysis of ATP, adenosine‐5′‐diphosphate (ADP) and adenosine‐5′‐monophosphate …

In this study, we have investigated the mechanism of ADP‐induced relaxation of porcine
coronary artery (PCA) rings. The P2Y receptor agonists ADP and ADPβS produced …

We previously demonstrated that uridine adenosine tetraphosphate (Up 4 A) exerts a potent
vasodilator effect in the healthy porcine coronary vasculature. Since the coronary …

We previously demonstrated that uridine adenosine tetraphosphate (Up 4 A) induces potent
and partially endothelium-dependent relaxation in the healthy porcine coronary …

Uridine adenosine tetraphosphate (Up4A) has been identified as an endothelium-derived
contracting factor, which acts through purinergic P2X and P2Y receptors. Since the coronary …

We cloned and sequenced the cDNA as well as the genomic DNA of the P2u receptor gene
from the rat. The coding region of the gene is not interrupted by introns. P2u is expressed in …