The transcriptional regulator STAT3 has key roles in vertebrate development and mature
tissue function including control of inflammation and immunity. Mutations in human STAT3 …

The Signal Transducer and Activator of Transcription (STAT)-5 proteins are required in
immune regulation and homeostasis and play a crucial role in the development and function …

The STAT3 story has almost 30 years of evolving history. First identified in 1994 as a pro-
inflammatory transcription factor, Signal Transducer and Activator of Transcription 3 (STAT3) …

Signal transducer and activator of transcription 4 (STAT4) is a central mediator in generating
inflammation during protective immune responses and immune-mediated diseases. In the 8 …

The discovery of new gain-of-function mutations in STAT3, as well as new studies among
patients with loss-of-function mutations, expand the understanding of the pathophysiology of …

Signal transducer and activator of transcription (STAT) proteins are critical mediators of
cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 …

Like other members of the signal transducer and activator of transcription (STAT) family of
proteins, STAT6 has a dual role as signaling molecule and transcription factor. STAT6 is …

STAT (signal transducers and activators of transcription) proteins are activated in response
to a large number of cytokines, growth factors, and hormones. Upon activation following the …

Jak/STAT pathways influence cell-fate decisions made by differentiating naïve T cells,
regulate the intensity and duration of inflammatory responses and are implicated in …

Since their discovery, STAT proteins have been intimately tied to controlling the
development of hematopoietic cells that regulate inflammation, and mediating the responses …