RATIONALE: We have shown that the rate of annual change in FEV was highly variable
among patients with chronic obstructive 1 pulmonary disease (COPD) and that lower body …

Introduction: COPD is a condition of global importance, characterised by accelerated lung
function decline and an abnormal inflammatory response. Exacerbations account for much …

Background: Adipose tissue, being an organ of the endocrine system, can influence the
severity of chronic obstructive pulmonary disease (COPD). Even though several …

Background: COPD is a multicomponent disease and systemic inflammation represents one
of the possible mechanisms responsible for its systemic manifestations, including skeletal …

Background: Adiponectin has been implicated to play a role in the pathophysiology of
chronic obstructive pulmonary disease (COPD). Many studies have assessed serum …

Chronic inflammation is present in many lung diseases, not only in airway diseases, like
asthma and chronic obstructive pulmonary disease (COPD), but also in interstitial lung …

ABSTRACT INTRODUCTION Exacerbations affect the natural history of chronic obstructive
pulmonary disease (COPD). OBJECTIVES The aim of the study was to evaluate the effect of …

Chronic obstructive pulmonary disease is one of the most common respiratory diseases in
which comorbid pathology is detected in almost 90% of patients. Particular attention in the …

Aims: The study aims to find out the role of APN as a marker of inflammation in the
pathogenesis of COPD and explore its relationship with the severity of the disease. Settings …

METHODS: Hokkaido COPD cohort study, which is a multi-center 5-year prospective cohort
study conducted in Japan as a development cohort, and the results were validated using …