Aim.–To identify the changes of mitochondrial protein expression in diabetic renal
parenchyma and to characterize their molecular functions and biological processes in …

Diabetes mellitus is a complex metabolic disorder characterized by chronic hyperglycemia
due to absolute or relative lack of insulin. Though great efforts have been made to …

It has been proposed that mitochondrial dysfunction is involved in the pathogenesis of type 2
diabetes (T2D). To dissect the underlying mechanisms, we performed a multiplexed …

Abstract Background and Aim Mitochondrial dysfunction contributes to the pathophysiology
of diabetic cardiomyopathy. The aim of this study was to investigate the acute changes in the …

Type 2 diabetes results from the development of insulin resistance and a concomitant
impairment of insulin secretion. Mitochondrial dysfunctions are thought to be the major …

Although mitochondrial reduction-oxidation (redox) stress and increase in membrane
permeability play an important role in diabetic-associated renal microvasculopathies, it is …

Quantitative protein profiling based on in vitro stable isotope labeling, two-dimensional
polyacrylamide gel electrophoresis, and mass spectrometry is an accurate and reliable …

Objective: Impaired mitochondrial function may contribute to the onset of contractile
dysfunction with insulin resistance/type 2 diabetes. Our aim was therefore to determine …

Diabetes now affects more than 5% of the world's population and heart failure is the most
common cause of death amongst diabetic patients. Accumulating evidence supports a view …

Mitochondrial dysfunction in muscle has been implicated to play a causative role or being an
indirect consequence of insulin resistance in type-2 diabetes. In order to investigate …