Using two-dimensional gel electrophoresis and liquid chromatography–tandem mass
spectrometry, we have used a systems biology approach to study the molecular basis of …

Background: Diabetic nephropathy (DN) is one of the most common chronic complications of
diabetes and the leading cause of end-stage renal disease. Recent research has found that …

Mitochondria are organelles that produce ATP and reactive oxygen species, which are
thought to be responsible for a decline in physiological function with aging. In this study, we …

Excessive action of angiotensin II on mitochondria has been shown to play an important role
in mitochondrial dysfunction, a common feature of atherogenesis and kidney injury …

Background Diabetes has become the single most common cause for end-stage renal
disease in the United States. It has been established that mitochondrial damage occurs …

Background Emerging evidence has linked mitochondrial dysfunction to the pathogenesis of
many renal disorders, including acute kidney injury, sepsis and even chronic kidney …

Background: Oxidative stress during the normoalbuminuric stage of type 1 diabetes mellitus
(DM) damages renal cortical mitochondria; hence, we aimed to determine if oxidative stress …

Diabetic cardiomyopathy (DCM) occurs independently of coronary artery disease or
hypertension, often leading to heart failure and death. Although remarkable progress has …

Extended hyperglycaemia leads to impaired glucose‐stimulated insulin secretion (GSIS)
and eventually β‐cell apoptosis in individuals with type 2 diabetes mellitus. In an attempt to …

Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance.
Metformin, a widely known anti-diabetic drug, used for patients with type 2 diabetes mellitus …