The functionality of the mitochondrion is primarily determined by nuclear encoded proteins.
The mitochondrial functional requirements of different tissues vary from a significant …

Background: The protein complexes of the electron transport chain have been linked to the
pathogenesis of diabetes mellitus (DM), but the interplay between DM and cytochrome c …

Insulin resistance plays a major role in the development of type 2 diabetes and obesity and
affects a number of biological processes such as mitochondrial biogenesis. Though …

Mitochondrion plays the key functions in mammalian cells. It is believed that mitochondrion
exerts the common biologic functions in many tissues, but also performs some specific …

Renal disease is a common complication of diabetes mellitus. The pathogenesis of diabetic
nephropathy is not well understood, but hyperglycemia seems to be a crucial factor. Recent …

Background/Aims: Chronic kidney disease (CKD) is closely correlated with the development
of insulin resistance (IR). Until now, the underlying molecular mechanisms remain to be …

Mitochondria-associated endoplasmic reticulum membranes (MAMs) are dynamic
membrane coupling regions formed by the coupling of the mitochondrial outer membrane …

The changes of mitochondrial function are closely related to diabetes and its complications.
Here we describe the effects of mitochondrial-derived peptides (MDPs), short peptides …

Mitochondrial dysfunction is an important mechanism contributing to the development and
progression of diabetic kidney disease (DKD). Mitochondrial DNA (mtDNA) levels in blood …

Abstract Type 2 Diabetes mellitus (T2DM) has become a major public health issue
associated with high risk of late onset of Alzheimer's disease (LOAD). Mitochondrial …