BACKGROUND: The role of mitochondrial dysfunction is currently studied intensively, but
the cumbersome procedure of obtaining tissue from humans has restricted the number of …

Thiazolidinediones address underlying causes of type 2 diabetes, although their mechanism
of action is not clearly understood. The compounds are thought to function as direct …

The Zucker diabetic fatty (ZDF) rat is a model of type II diabetes and metabolic syndrome
based on impaired glucose tolerance caused by the inherited insulin-resistance gene. The …

Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes.
Background More than half of the new patients admitted to dialysis therapy in some centers …

Introduction Diabetic nephropathy (DN) develops in about 40% of patients with type 2
diabetes and remains the leading cause of end-stage renal disease. The mechanisms of DN …

Aims. We investigated the changes of renal structure and its function in normal glucose
tolerance (NGT), impaired glucose tolerance (IGT), diabetes mellitus (DM), and diabetic …

Objective The objective of this study was to evaluate the role of oxidative stress in an
experimental model of streptozotocin-induced diabetic nephropathy in rats. Materials and …

Aims/hypothesis The renal medullary region is particularly vulnerable to reduced oxygen
concentration because of its low blood perfusion and high basal oxygen consumption. This …

Abstract Analysis of the mitochondrial proteome would provide valuable insight into the
function of this important organelle, which plays key roles in energy metabolism, apoptosis …

Major reason for mortality among systemic lupus erythematosus patients is renal failure due
to the deposition of immune complexes in the glomeruli. Being a chronic disease with …