Mitochondrial dysfunction is a potentially important player in the development of insulin
resistance and type 2 diabetes mellitus (T2DM). We investigated the changes of mRNA …

DIABETES MELLITUS IS INCREASINGLY common throughout the world, due to both an
increase in incidence and to decreased mortality of those with diabetes. Unfortunately …

Type-1 diabetes resulting from defective insulin secretion and consequent hyperglycemia, is
associated with “diabetic encephalopathy.” This is characterized by brain …

In healthy kidneys, interstitial fibroblasts are responsible for the maintenance of renal
architecture. Progressive interstitial fibrosis is thought to be a common pathway for chronic …

Background To investigate the pathogenesis of diabetic nephropathy (DN) and to search for
novel therapeutic targets, the glomerular protein expression profile of KKAy mice treated by …

Background Advanced glycation end products (AGEs) are pathogenic factors of diabetic
nephropathy (DN), causing renal damage in various ways. The aim of this study is to …

Mitochondrial dysfunction is recently thought to be tightly associated with the development of
cardiac hypertrophy as well as hypertension. However, the detailed molecular events in …

Diabetes mellitus (DM) is a chronic progressive disease that often results in microvascular
and macrovascular complications, yet its pathogenesis is not clear. Automated proteomic …

Methods: To verify the effect of hyperglycemia on renal tissue, we observed the cell growth
inhibition rate by adding different concentration of glucose to cell supernatant. After that, a …

The focus of this review is on the proteomic approaches applied to the study of the
qualitative/quantitative changes in mitochondrial proteins that are related to impaired …