Inhibition of mitochondrial β-oxidation by miR-107 promotes hepatic lipid accumulation and impairs glucose tolerance in vivo

H Bhatia, BR Pattnaik, M Datta - International journal of obesity, 2016 - nature.com
Background: Hepatic expression of microRNA-107 is ubiquitously upregulated in various
metabolic diseases. In our previous study, we had demonstrated that fatty acid synthase …

[HTML][HTML] MicroRNA-185 regulates expression of lipid metabolism genes and improves insulin sensitivity in mice with non-alcoholic fatty liver disease

XC Wang, XR Zhan, XY Li, JJ Yu… - World journal of …, 2014 - ncbi.nlm.nih.gov
AIM: To assess the regulatory effect of microRNA-185 (miR-185) on lipid metabolism and the
insulin signalling pathway in human HepG2 hepatocytes and a high-fat diet mouse model …

[HTML][HTML] MicroRNA-194 inhibition improves dietary-induced non-alcoholic fatty liver disease in mice through targeting on FXR

H Nie, C Song, D Wang, S Cui, T Ren, Z Cao… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) affects obesity-associated metabolic syndrome,
which exhibits hepatic steatosis, insulin insensitivity and glucose intolerance. Previous …

MiR-150 deficiency ameliorated hepatosteatosis and insulin resistance in nonalcoholic fatty liver disease via targeting CASP8 and FADD-like apoptosis regulator

B Zhuge, G Li - Biochemical and biophysical research communications, 2017 - Elsevier
The prevalence of Non-alcoholic fatty liver diseases (NAFLD) increased rapidly in the world.
However, the pathogenesis of is still unclear. Hepatic steatosis and insulin resistance are …

[HTML][HTML] A negative feedback loop between microRNA-378 and Nrf1 promotes the development of hepatosteatosis in mice treated with a high fat diet

T Zhang, X Zhao, CJ Steer, G Yan, G Song - Metabolism, 2018 - Elsevier
Backgrounds The incidence of nonalcoholic fatty liver disease (NAFLD) is rapidly increasing
due to the prevalence of obesity. NAFLD is a major risk factor of hepatocellular carcinoma …

Hepatocyte miR‐33a mediates mitochondrial dysfunction and hepatosteatosis by suppressing NDUFA5

H Nie, X Yu, H He, L Zhou, Q Li, C Song… - Journal of Cellular …, 2018 - Wiley Online Library
Emerging evidence suggests that microRNAs (miRNAs) are essential for metabolic
haemostasis of liver tissues. Among them, miR‐33a is supposed to modulate the cholesterol …

miR‑146a improves hepatic lipid and glucose metabolism by targeting MED1

K Li, B Zhao, D Wei, W Wang… - International …, 2020 - spandidos-publications.com
Non‑alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases
worldwide. Increasing evidence has shown that microRNAs (miRNAs) play a vital role in the …

MicroRNA‐30b regulates insulin sensitivity by targeting SERCA2b in non‐alcoholic fatty liver disease

LL Dai, SD Li, YC Ma, JR Tang, JY Lv… - Liver …, 2019 - Wiley Online Library
Abstract Background & Aims Insulin resistance is strongly associated with non‐alcoholic
fatty liver disease, a chronic, obesity–related liver disease. Increased endoplasmic reticulum …

miR‐26a potentially contributes to the regulation of fatty acid and sterol metabolism in vitro human HepG2 cell model of nonalcoholic fatty liver disease

O Ali, HA Darwish, KM Eldeib… - Oxidative Medicine and …, 2018 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a metabolic‐related disorder ranging from
steatosis to steatohepatitis, which may progress to cirrhosis and hepatocellular carcinoma …

MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice

AM Miller, DS Gilchrist, J Nijjar, E Araldi, CM Ramirez… - PloS one, 2013 - journals.plos.org
Hepatic steatosis is a global epidemic that is thought to contribute to the pathogenesis of
type 2 diabetes. MicroRNAs (miRs) are regulators that can functionally integrate a range of …