Clinicians need to know whether duloxetine is effective in patients across a broad range of
depressive symptoms and depression severity. Data were pooled from nine randomized …

OBJECTIVE: This analysis focuses on efficacy and safety data obtained from studies of
duloxetine for the treatment of major depressive disorder (MDD) within the approved dose …

Background: Duloxetine is a balanced and potent dual reuptake inhibitor of serotonin (5-HT)
and norepinephrine (NE) that has previously been shown to be effective in the acute …

Duloxetine, an inhibitor of serotonin and norepinephrine reuptake, has been approved for
the treatment of major depressive disorder. In this analysis, data from eight, double-blind …

Background The most prominent feature of melancholic depression is a near-total loss of the
capacity to derive pleasure from activities or other positive stimuli. Additional symptoms can …

Objective: Duloxetine doses of 80 and 120 mg/day were assessed for efficacy and safety in
the treatment of major depressive disorder (MDD). Methods: In this randomized, double …

Background. This study compares the efficacy and tolerability of 12 weeks of open-label
duloxetine in adult outpatients with anxious versus non-anxious depression. Methods …

OBJECTIVE: At effective doses, patients with major depressive disorder (MDD) treated with
duloxetine have been found to experience significant symptom improvement as measured …

Background: Duloxetine hydrochloride, a dual reuptake inhibitor of serotonin and
norepinephrine, was evaluated for therapeutic efficacy and safety/tolerability in the treatment …

Objective To examine the safety and tolerability of the antidepressant duloxetine across
multiple studies for major depressive disorder (MDD). Method Safety data were integrated …