Calcium antagonists are uniquely suitable for managing hypertension by virtue of their
efficacy, metabolic neutrality and their ability to countervail counter-regulatory adaptive …

Lacidipine, currently being evaluated as a once-daily antihypertensive agent, acted as a
calcium entry blocker on rabbit ear artery (pA 2= 9.4) with a markedly slower onset of action …

The safety and tolerability of lacidipine was assessed in a volunteer population, and its
pharmacodynamic and pharmacokinetic profiles evaluated. In nor-motensive subjects …

Evaluating the benefits of an antihypertensive agent using t... : Journal of Hypertension
Evaluating the benefits of an antihypertensive agent using trials based on event and organ …

This randomised, double-blind, double-dummy, parallel group, multicentre study compared
the efficacy and tolerability of lercanidipine with lacidipine. Elderly patients with isolated …

Lacidipine, a third generation dihydropyridine calciumantagonist, has demonstrated
pronounced anti-atherosclerotic activity in preclinical studies. The drug can act at several …

Background—Most cardiovascular events associated with hypertension are complications of
atherosclerosis. Some antihypertensive agents influence experimental models of …

Lercanidipine is a lipophilic, dihydropyridine calcium antagonist with a long receptor half-
life. Its slow onset of action helps to avoid reflex tachycardia associated with other …

Isolated systolic hypertension (ISH) is a definite risk factor for cardiovascular complications
(ie, cardiac failure, coronary artery disease, and stroke) independent of diastolic elevation …