Lipophilic dihydropyridines have many theoretical and practical clinical advantages owing to
their long permanence at the cell membrane. They have a greater chance of smoothly and …

Systemic hypertension is a major global problem contributing to enormous disease burden,
premature morbidity and mortality. A substantial majority of hypertensive patients require …

The TOLERANCE study was aimed to compare the tolerability of high doses of lercanidipine
(20 mg) with that of other frequently used dihydropyridines (amlodipine 10 mg/nifedipine …

Synopsis Nilvadipine, a calcium antagonist of the dihydropyridine class, selectively blocks
calcium channels in vascular smooth muscle. Compared with nifedipine, the prototype of the …

Objective: To prospectively compare the individual tolerability of Lercanidipine (L) in
hypertensive patients with drug-specific side effects during the treatment with some …

Two ambulatory blood pressure monitoring (ABPM) studies were performed to define the
antihypertensive activity and the tolerability of lercanidipine. a new longacting …

The second half of the 20th century has seen a constant de-crease in cardiovascular
mortality in the Western industrialised nations [1]. This decrease has occurred concomitantly …

NORDIL-the Nordic diltiazem intervention study was started in September 1992. This trial is
a prospective randomized open blinded-endpoint (PROBE) multicenter, parallel-group study …

Several classes of antihypertensive agents have been in clinical use, including diuretics, α-
blockers, β-blockers, angiotensin converting enzyme (ACE) inhibitors, angiotensin II type 1 …

Objectives Cilnidipine is a calcium channel blocker that blocks both L and N-type calcium
channels. L/N-type calcium channel blockers exhibit sympatholytic action and a renal …