Klotho is an anti-aging protein that is mostly secreted by the kidneys, the brain, and the
thyroid. It plays a significant role in regulating kidney function and vascular health. Klotho …

The aging suppressor geneKlotho is predominantly expressed in the kidney irrespective of
species. Because Klotho protein is an essential component of an endocrine axis that …

Since the discovery of klotho as an anti-aging gene, its association with tumors has been
studied. Several previous studies have reported the down-expression of klotho in various …

Background Klotho, a single-pass transmembrane protein associated with premature aging,
acts as a tumor suppressor gene by inhibiting insulin/insulin-like growth factor-1 and …

Objective To determine DNA methylation status of ZIC1 and KLOTHO gene in colorectal
carcinomas and its relationship with clinicopathological features of patients. Methods The …

Klotho, an anti-aging gene, has recently been shown to contribute to human hepatic
tumorigenesis. In addition, it is known that Wnt signaling is antagonized by the protein …

Aging is a natural process, which shows itself as anatomical and physiological changes in
living organisms in the course of time. There are both environmental and genetic factors …

Simple Summary We aimed to study the role of the anti-aging protein klotho and its secreted
isoform, sKL, in pancreatic cancer. Three in vivo models, including a novel genetic mouse …

Background: Colorectal cancer susceptibility may correlate with the Klotho gene G-395A
and C1818T polymorphisms. This study aims to evaluate the relationship between a Klotho …

Klotho is a recently discovered anti‑aging gene, which has been reported as a tumor
suppressor in numerous human malignancies; however, the role of Klotho in human ovarian …