Sickle cell disease results in significant morbidity and mortality for those affected with this
disease. Despite the fact that every case of sickle cell disease results from the same genetic …

The first clinical description of sickle cell anemia was published in 1910 by Herri~ k?~ who
reported some of the clinical and hematologic manifestations of the disorder in a 20-year-old …

Treatment advances over the past 25 years have significantly decreased morbidity and
mortality in children with sickle cell disease. Aggressive management of fever, early …

In the United States, sickle cell disease affects approximately 1 in 350 African-American
newborn infants each year, and approximately 72,000 individuals total. Sickle cell disease is …

Sickle cell disease (SCD) is a serious and life-threatening disease that affects approximately
1 in 600 African Americans [1, 2]. In 1910, Herrick described the first patient with SCD, and …

This article summarizes my presentation at the Pediatric Hematology‐Oncology Symposium
in honor of Dr. Stephen A. Feig in April 2005. Areas highlighted reflect key topics whose …

As a global health problem, sickle cell anemia affects many world populations. Since its
initial description in the United States almost a century ago, scientists and medical …

Sickle cell disease is enormously variable in its expression and outcome. In addition to this
intrinsic variability are the problems of symptomatic selection biasing observations towards …

Sickle cell disease is an autosomal recessive, multisystem disorder, characterised by
chronic haemolytic anaemia, painful episodes of vaso-occlusion, progressive organ failure …

Background: Sickle cell disease causes significant morbidity and mortality and affects the
economic and healthcare status of many countries. Yet historically, the disease has not had …