Objective: Previously we reported that exposure of 6‐day‐old (P6) rhesus macaques to
isoflurane for 5 hours triggers a robust neuroapoptosis response in developing brain. We …

Previously we reported that a 5-hour exposure of 6-day-old (P6) rhesus macaques to
isoflurane triggers robust neuron and oligodendrocyte apoptosis. In an attempt to further …

Background: The authors have previously shown that exposure of the neonatal nonhuman
primate (NHP) brain to isoflurane for 5 h causes widespread acute apoptotic degeneration of …

BACKGROUND: Accumulating evidence indicates that isoflurane and other, similarly acting
anesthetics exert neurotoxic effects in neonatal animals. However, neither the identity of …

Background Brief isoflurane anesthesia induces neuroapoptosis in the developing rodent
brain, but susceptibility of non-human primates to the apoptogenic action of isoflurane has …

The effect of general anesthetics on the developing brain is receiving growing attention.
Nonetheless, there remains a paucity of evidence regarding the effect of sevoflurane, a …

Background: Retrospective clinical studies suggest there is a risk for neurodevelopmental
impairment following early childhood exposure to anaesthesia. In the developing animal …

Background Exposure of the fetal or neonatal non-human primate (NHP) brain to isoflurane
or ketamine for 5 h causes widespread apoptotic degeneration of neurones, and exposure …

BACKGROUND: Volatile anesthetics, such as isoflurane, are widely used in infants and
neonates. Neurodegeneration and neurocognitive impairment after exposure to isoflurane …

Drugs that suppress neuronal activity, including general anesthetics used in pediatric and
obstetric medicine, trigger neuroapoptosis in the developing rodent brain. Exposure of infant …