Protein kinase (PK) Cθ and Akt/PKBα cooperate in T cell receptor/CD28-induced T cell
signaling. We here demonstrate the recruitment of endogenous Akt1 and PKCθ to lipid rafts …

T-cell biological responses appear to involve the complex interaction of T-cell surface
receptors, intracellular signaling molecules and the cytoskeleton. Both the serine/threonine …

Protein kinase C θ (PKC-θ), one of many PKC isoforms expressed in T cells, is important for
the activation of mature effector T cells. During T cell activation, PKC-θ is recruited to the …

PKCθ plays an essential role in activation of mature T cells via stimulation of AP-1 and NF-
κB, and is known to selectively translocate to the immunological synapse in antigen …

Akt signaling plays a central role in T cell functions, such as proliferation, apoptosis, and
regulatory T cell development. Phosphorylation at Ser473 in the hydrophobic motif, along …

Protein kinase Cθ (PKCθ) is known to induce NF-κB, an essential transcriptional element in
T cell receptor/CD28-mediated interleukin-2 production but also T cell survival. Here we …

Using yeast two-hybrid, we isolated atypical PKCζ as a PKCθ-interacting kinase and
demonstrated that it selectively interacted with, and was phosphorylated by, PKCθ …

The novel protein kinase C (PKC) isoform, PKCθ, is expressed in a relatively selective
manner in T lymphocytes (and muscle). Recent analysis of this PKC isotype in T cells and …

The serine/threonine kinase Akt (also known as protein kinase B)(Akt/PKB) is activated upon
T-cell antigen receptor (TCR) engagement or upon expression of an active form of …

The E3 ubiquitin ligase Casitas B-lineage lymphoma (Cbl-b) is central to antigen-induced
immune tolerance and regulates the CD28 dependence of T cell activation. Cbl-b …