Cerebral blood flow increases at high altitude, but the mechanism of the increase and its
role in adaptation to high altitude are unclear. We hypothesized that the hypoxemia at high …

Non‐technical summary Brain blood flow increases during the first week of living at high
altitude. We do not understand completely what causes the increase or how the factors that …

Cerebral blood flow and O2 delivery during exercise are important for well-being at altitude
but have not been studied. We expected flow to increase on arrival at altitude and then to fall …

Cerebral blood flow is known to increase in response to hypoxia and to decrease with
hypocapnia. It is not known, however, whether these responses are altered in high‐altitude …

Cerebral blood flow increases with acute exposure to high altitude, but the effect of hypoxia
on the cerebral circulation at rest and during exercise appears influenced by the duration of …

New Findings What is the central question of this study? Hypoxia associated with ascent to
high altitude may threaten cerebral oxygen delivery. We sought to determine whether there …

Cerebral blood flow increases on exposure to high altitude, and perhaps more so in subjects
who develop acute mountain sickness. We determined cerebral blood flow by transcranial …

The interindividual variation in ventilatory acclimatization to high altitude is likely reflected in
variability in the cerebrovascular responses to high altitude, particularly between brain …

The effects of partial acclimatization to high altitude (HA; 5,050 m) on cerebral metabolism
and cerebrovascular function have not been characterized. We hypothesized (1) increased …

The cause of headache in persons going to high altitude is unknown. Relatively severe
hypoxemia in susceptible subjects could induce large increases in cerebral blood flow that …