The INK4A/ARF locus: role in cell cycle control and apoptosis and implications for glioma growth
Abstract The unique INK4A/ARF locus at chromosome 9p21 encodes two distinct proteins
that intimately link the pRB and p53 tumour suppressor pathways. p16 INK4A has been …
that intimately link the pRB and p53 tumour suppressor pathways. p16 INK4A has been …
[HTML][HTML] Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19 ARF
T Kamijo, F Zindy, MF Roussel, DE Quelle, JR Downing… - Cell, 1997 - cell.com
The INK4a tumor suppressor locus encodes p16 INK4a, an inhibitor of cyclin D-dependent
kinases, and p19 ARF, an alternative reading frame protein that also blocks cell proliferation …
kinases, and p19 ARF, an alternative reading frame protein that also blocks cell proliferation …
Loss of p21 disrupts p14ARF-induced G1 cell cycle arrest but augments p14ARF-induced apoptosis in human carcinoma cells
PG Hemmati, G Normand, B Verdoodt, C von Haefen… - Oncogene, 2005 - nature.com
The human INK4a locus encodes two structurally unrelated tumor suppressor proteins, p16
INK4a and p14 ARF (p19 ARF in the mouse), which are frequently inactivated in human …
INK4a and p14 ARF (p19 ARF in the mouse), which are frequently inactivated in human …
Tumor suppression by Ink4a–Arf: progress and puzzles
SW Lowe, CJ Sherr - Current opinion in genetics & development, 2003 - Elsevier
The two products of the Ink4a–Arf locus, p16Ink4a and p19Arf (p14ARF in humans), are
potent tumor suppressors that regulate the activities of the retinoblastoma protein and the …
potent tumor suppressors that regulate the activities of the retinoblastoma protein and the …
The INK4a/ARF locus in murine tumorigenesis
M Serrano - Carcinogenesis, 2000 - academic.oup.com
The INK4a/ARF locus is regarded as one of the most important anti-tumoral defenses that
mammalian organisms possess. The characterization of its two gene products, p16INK4a …
mammalian organisms possess. The characterization of its two gene products, p16INK4a …
[PDF][PDF] The tumor-suppressive functions of the human INK4A locus
PM Voorhoeve, R Agami - Cancer cell, 2003 - cell.com
The INK4A locus is often inactivated in human cancer. INK4A encodes for p14 ARF and p16
INK4A that inhibit growth through p53 and pRb, respectively. We used RNA interference …
INK4A that inhibit growth through p53 and pRb, respectively. We used RNA interference …
INK4a/ARF: a multifunctional tumor suppressor locus
NE Sharpless - … Research/Fundamental and Molecular Mechanisms of …, 2005 - Elsevier
The INK4a/ARF locus encodes two physically linked tumor suppressor proteins, p16INK4a
and ARF, which regulate the RB and p53 pathways, respectively. The unusual genomic …
and ARF, which regulate the RB and p53 pathways, respectively. The unusual genomic …
Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all
J Gil, G Peters - Nature reviews Molecular cell biology, 2006 - nature.com
Abstract The INK4b–ARF–INK4a locus encodes two members of the INK4 family of cyclin-
dependent kinase inhibitors, p15 INK4b and p16 INK4a, and a completely unrelated protein …
dependent kinase inhibitors, p15 INK4b and p16 INK4a, and a completely unrelated protein …
[HTML][HTML] Role of the INK4a locus in tumor suppression and cell mortality
The cell cycle inhibitor p16 INK4a is inactivated in many human tumors and in families with
hereditary melanoma and pancreatic cancer. Tumor-associated alterations in the INK4a …
hereditary melanoma and pancreatic cancer. Tumor-associated alterations in the INK4a …
Quantitative real-time PCR does not show selective targeting of p14ARF but concomitant inactivation of both p16INK4A and p14ARF in 105 human primary gliomas
M Labuhn, G Jones, EJM Speel, D Maier, C Zweifel… - Oncogene, 2001 - nature.com
In many human cancers, the INK4A locus is frequently mutated by homozygous deletions.
By alternative splicing this locus encodes two non-related tumor suppressor genes, p16 …
By alternative splicing this locus encodes two non-related tumor suppressor genes, p16 …