Over the last years, hypothalamic inflammation has been linked to the development and
progression of obesity and its sequelae. There is accumulating evidence that this …

Diet-induced obesity leads to devastating and common chronic diseases, fueling ongoing
interest in determining new mechanisms underlying both obesity and its consequences. It is …

Inflammatory reaction is a fundamental defense mechanism against threat towards normal
integrity and physiology. On the other hand, chronic diseases such as obesity, type 2 …

Obesity and its comorbidities are long-standing, challenging global health problems. Lack of
exercise, overnutrition, and especially the consumption of fat-rich foods are some of the most …

The hypothalamus is one of the master regulators of various physiological processes,
including energy balance and nutrient metabolism. These regulatory functions are mediated …

Accumulated preclinical literature demonstrates that hypothalamic inflammation and gliosis
are underlying causal components of diet-induced obesity in rodent models. This review …

Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in
peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the …

Determining the effect of hypothalamic inflammatory signals on energy balance presents a
paradox. On the one hand, a large body of work has identified inflammatory signaling in the …

Obesity is one of the worldwide prevalent disease caused by the imbalance between food
intake and energy expenditure. Over a 100 years of research demonstrate that …

Findings from rodent and human studies show that the presence of inflammatory factors is
positively correlated with obesity and the metabolic syndrome. Obesity-associated …