[HTML][HTML] Systematic characterization of multi-omics landscape between gut microbial metabolites and GPCRome in Alzheimer's disease

Y Qiu, Y Hou, D Gohel, Y Zhou, J Xu, M Bykova… - Cell Reports, 2024 - cell.com
Shifts in the magnitude and nature of gut microbial metabolites have been implicated in
Alzheimer's disease (AD), but the host receptors that sense and respond to these …

Comprehensive characterization of multi-omic landscapes between gut-microbiota metabolites and the G-protein-coupled receptors in Alzheimer's disease

Y Qiu, Y Hou, Y Zhou, J Xu, M Bykova, JB Leverenz… - bioRxiv, 2022 - biorxiv.org
Accumulating evidence suggests that gut-microbiota metabolites contribute to human
disease pathophysiology, yet the host receptors that sense these metabolites are largely …

[HTML][HTML] A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer's disease

F Favero, E Barberis, M Gagliardi, S Espinoza, L Contu… - Plos one, 2022 - journals.plos.org
The key role played by host-microbiota interactions on human health, disease onset and
progression, and on host response to treatments has increasingly emerged in the latest …

[HTML][HTML] Bridging the gap between gut microbiota and Alzheimer's disease: a metaproteomic approach for biomarker discovery in transgenic mice

E Ayan, H DeMirci, MA Serdar, F Palermo… - International Journal of …, 2023 - mdpi.com
Alzheimer's Disease (AD) is a progressively debilitating form of dementia that affects millions
of individuals worldwide. Although a vast amount of research has investigated the complex …

Gut microbiota-driven metabolic alterations reveal gut–brain communication in Alzheimer's disease model mice

Y Chen, Y Li, Y Fan, S Chen, L Chen, Y Chen… - Gut …, 2024 - Taylor & Francis
The gut microbiota (GM) and its metabolites affect the host nervous system and are involved
in the pathogeneses of various neurological diseases. However, the specific GM alterations …

[HTML][HTML] Disturbed microbial ecology in Alzheimer's disease: Evidence from the gut microbiota and fecal metabolome

J Xi, D Ding, H Zhu, R Wang, F Su, W Wu, Z Xiao… - BMC microbiology, 2021 - Springer
Background Gut microbiota (GMB) alteration has been reported to influence the Alzheimer's
disease (AD) pathogenesis through immune, endocrine, and metabolic pathways. This study …

Unraveling Alzheimer's: Exploring the Gut Microbiota–Brain Axis as a New Frontier in Understanding

SM Rashid, R Razak, AK Tantray, AW James… - Journal of Dementia …, 2024 - mdpi.com
The gut microbiota (GM) communicates with the brain via biochemical signaling constituting
the gut–brain axis, which significantly regulates the body's physiological processes. The GM …

[HTML][HTML] An integrated neuroimaging-omics approach for the gut-brain communication pathways in Alzheimer's disease

C Sheng, W Du, Y Liang, P Xu, Q Ding… - Frontiers in Aging …, 2023 - frontiersin.org
A key role of the gut microbiota in the pathogenesis of neurodegenerative diseases, such as
Alzheimer's disease (AD), has been identified over the past decades. Increasing clinical and …

Fecal 16S rRNA sequencing and multi-compartment metabolomics revealed gut microbiota and metabolites interactions in APP/PS1 mice

X Cheng, Y Tan, H Li, J Huang, D Zhao, Z Zhang… - Computers in Biology …, 2022 - Elsevier
Background Alzheimer's disease is a significant public health issue. Recent studies have
shown that the gut microbiota plays a vital role in the onset and development of Alzheimer's …

[HTML][HTML] The potential of the gut microbiome for identifying Alzheimer's disease diagnostic biomarkers and future therapies

Y Zhan, M Al-Nusaif, C Ding, L Zhao… - Frontiers in …, 2023 - frontiersin.org
Being isolated from the peripheral system by the blood–brain barrier, the brain has long
been considered a completely impervious tissue. However, recent findings show that the gut …