We have previously described a subset of subjects with essential hypertension who fail to
appropriately modulate renal vascular and adrenal reactivity with changes in dietary sodium …

In normal subjects, dietary sodium intake modulates renovascular, adrenal, and pressor
responses to infused angiotensin II (AII). To examine the hypothesis that this modulation is …

Normotensive young men (mean age 36 years) with positive (PFH)(n= 13) and negative (n=
29) family histories of hypertension were investigated in order to study systemic and renal …

A subset of essential hypertensives sensitive to salt and having normal or high renin levels
are termed nonmodulators. These subjects fail to modulate their renal blood flow and …

Non-modulation is a trait characterized by abnormal angiotensin-mediated control of
aldosterone release and the renal blood supply. To determine whether non-modulation …

In 40 to 50 percent of the essential hypertensive population, a high intake of sodium does
not increase renal blood flow. These patients have been called “non-modulators” since their …

In 40-50% of patients with essential hypertension, a high sodium intake does not increase
renal blood flow (RBF). These patients have been defined as nonmodulators because …

Because an inherited renal factor may contribute to essential hypertension in humans, the
study of family members is attractive. To assess the determinants of renal vascular tone …

The responsiveness of plasma aldosterone to an angiotensin (Ang) II infusion was assessed
in normotensive young men, nine without and 13 with a family history of essential …

A continuing medical education quiz on this article (one hour of Category 1 credit) appears
on page A125 of this issue. This study assessed renal sodium handling in a group of …