The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat

S Rassnick, L Stinus, GF Koob - Brain research, 1993 - Elsevier
Rats readily learn to self-administer ethanol using a procedure where ethanol is introduced
in the presence of a sweetener. After gradual removal of the sweetener, sufficient quantities …

Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants.

F Weiss, MT Lorang, FE Bloom, GF Koob - Journal of Pharmacology and …, 1993 - ASPET
Dopaminergic neurotransmission in the nucleus accumbens may be an important factor in
ethanol reinforcement and genetically determined ethanol preference. This hypothesis was …

Effect of operant self‐administration of 10% ethanol plus 10% sucrose on dopamine and ethanol concentrations in the nucleus accumbens

WM Doyon, SK Anders… - Journal of …, 2005 - Wiley Online Library
Although operant ethanol self‐administration can increase accumbal dopamine activity, the
relationship between dopamine and ethanol levels during consumption remains unclear …

Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens

S Rassnick, L Pulvirenti, GF Koob - Psychopharmacology, 1992 - Springer
The purpose of this study was to assess the role of endogenous dopamine and glutamate
systems within the nucleus accumbens in modulating responses for oral ethanol …

Effect of dopamine agonists and antagonists on ethanol-reinforced behavior: the involvement of the nucleus accumbens

HH Samson, CW Hodge, GA Tolliver, M Haraguchi - Brain research bulletin, 1993 - Elsevier
Rats initiated to self-administer 10% ethanol (v/v) in an operant situation using the sucrose-
substitution technique received bilateral n. accumbens or caudate nucleus microinjections of …

Microdialysis of dopamine in the nucleus accumbens of alcohol‐preferring (P) rats during anticipation and operant self‐administration of ethanol

RI Melendez, ZA Rodd‐Henricks… - Alcoholism: Clinical …, 2002 - Wiley Online Library
Background: The present study was designed to test directly whether a contextual stimulus
for access to ethanol would acquire the ability to enhance locomotor activity and dopamine …

[引用][C] Lack of effect of dopamine receptor blockade on voluntary ethanol consumption in rats

ZW Brown, K Gill, M Abitbol, Z Amit - Behavioral and neural biology, 1982 - Elsevier
Alcohol-drinking male Wistar rats consuming a 10% v/v ethanol solution presented in a free
choice with water did not alter their intake of ethanol during 5 days of treatment with …

Dopamine activity in the nucleus accumbens during consummatory phases of oral ethanol self‐administration

WM Doyon, JL York, LM Diaz… - Alcoholism: Clinical …, 2003 - Wiley Online Library
Background: This present study was designed to clarify the role of dopamine in the nucleus
accumbens during operant ethanol self‐administration by separating bar pressing (ethanol …

Alcohol self-administration: role of mesolimbic dopamine.

HH Samson, GA Tolliver, M Haraguchi… - Annals of the New York …, 1992 - europepmc.org
It appears clear that ethanol reinforcement, like that of many abused drugs, utilizes the
mesolimbic DA pathways. From the data presented on microinjection of DA agonists and …

The role of mesolimbic dopamine in the development and maintenance of ethanol reinforcement

RA Gonzales, MO Job, WM Doyon - Pharmacology & therapeutics, 2004 - Elsevier
The neurobiological processes by which ethanol seeking and consumption are established
and maintained are thought to involve areas of the brain that mediate motivated behavior …