Background The cytotoxicity of NK cells is largely dependent on IgG Fc receptor CD16a,
which mediates antibody-dependent cell-mediated cytotoxicity (ADCC). The high-affinity and …

CD16A is a potent cytotoxicity receptor on human natural killer (NK) cells, which can be
exploited by therapeutic bispecific antibodies. So far, the effects of CD16A-mediated …

Background Antibody therapies can direct natural killer (NK) cells to tumor cells, tumor-
associated cells, and suppressive immune cells to mediate antibody-dependent cell …

Natural killer (NK) cells, as a potential source for off-the-shelf cell therapy, attack tumor cells
with low risk of severe cytokine release syndrome (CRS) or graft-versus-host disease …

The generation and expansion of functionally competent NK cells in vitro is of great interest
for their application in immunotherapy of cancer. Since CD33 constitutes a promising target …

Simple Summary Natural Killer (NK) cells play a major role in cancer immunotherapy based
on tumor-targeting mAbs. NK cell-mediated tumor cell killing and cytokine secretion are …

Natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity (ADCC), based on
the recognition of IgG-opsonized targets by the low-affinity receptor for IgG FcγRIIIA/CD16 …

Antibody-dependent cell-mediated cytotoxicity (ADCC) is a potent cytotoxic mechanism that
is mainly mediated in humans by natural killer (NK) cells. ADCC mediates the clinical benefit …

The field of immuno-oncology has revolutionized cancer patient care and improved survival
and quality of life for patients. Much of the focus in the field has been on exploiting the power …

Abstract Purpose: Natural killer (NK)-cell recognition and function against NK-resistant
cancers remain substantial barriers to the broad application of NK-cell immunotherapy …